Immunocytochimical Evidence for Interleukin-2 Receptor Regulation on Rat Anterior Pituitary and Adrenal Cells

この論文にアクセスする

この論文をさがす

著者

抄録

Using a specific monoclonal antibody (mAb) recognizing the rat interleukin-2 receptor (IL-2R) and immunocytochemical techniques, we examined the expression of IL-2R in rat anterior pituitary and adrenal cells <i>in vitro</i>. IL-2R immunoreactivity was seen in a variety types of cells in both the pituitary and adrenals. Under the condition to detect the IL-2R-like immunoreactivity, we found that overnight preincubation with IL-2 enhanced the immunostaining in these cells. Moreover, co-incubation of the cells with dexamethasone attenuated the effect of IL-2 on the IL-2R-like immunostaining. These findings indicate that IL-2R expression in the pituitary and adrenal cells is influenced by IL-2 and glucocorticoid, and support the hypothesis that IL-2 is an immunomediator affecting the pituitary and the adrenal function.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 29(3), 255-260, 1996-06-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

参考文献:  30件中 1-30件 を表示

各種コード

  • NII論文ID(NAID)
    10008605608
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  J-STAGE 
ページトップへ