Prenatal and Postnatal Development of NO Synthase and NADPH Diaphorase in Juxtagomerular Region of Rat Kidney

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著者

    • AOKI Eiko
    • Department of Embryology, Institute for Developmental Research, Aichi Human Service Center
    • SEMBA Reiji
    • Department of Anatomy, Mie University School of Medicine
    • YING Hu
    • Department of Anatomy, Mie University School of Medicine
    • NING Ma
    • Department of Anatomy, Mie University School of Medicine
    • TAKEUCHI Ikuo
    • Department of Embryology, Institute for Developmental Research, Aichi Human Service Center

抄録

Prenatal and postnatal development of neuronal NO synthase (nNOS) immunoreactivity and NADPH diaphorase (NADPHd) histochemical activity were studied in the rat kidney. NADPHd activity appeared at prenatal day 18, and nNOS immunoreactivity was first detected at prenatal day 19. However, these activities were rarely found before the prenatal day 20, and their staining intensity was very weak. Neuronal NOS protein and NADPHd activity appeared first in the inner layer of renal cortex. In higher magnification, they localized not only in macula densa cells but also in perimacular epithelial cells connected to the macula densa. With development, the number of nNOS immunoreactive and NADPHd positive sites increased dramatically and many nNOS-positive maculae densae were detected in the juxtamedullary region of the cortex at postnatal day 5. At postnatal day 14, the staining pattern of nNOS and NADPHd was similar to that of adults. NADPHd activity and nNOS immunoreactivity were found in very early stages of nephrogenesis including in prenatal days before full development of the glomerulus.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 29(4), 339-343, 1996-08-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

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各種コード

  • NII論文ID(NAID)
    10008605880
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00445991
  • データ提供元
    CJP書誌  J-STAGE 
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