Autoimmune Diseases as "Stem Cell Disorders"

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Using various animal models for autoimmune diseases, we have found that bone marrow transplantation (BMT) can be used to treat not only systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), but also organspecific autoimmune diseases such as immune thrombocytopenic purpura (ITP) and insulin-dependent diabetes mellitus (IDDM). We have also found that the transplantation of hemopoietic stem cell (HSC) -enriched populations from autoimmune-prone mice to normal mice induces autoimmune diseases in the recipients. These findings have recently been confirmed in humans; BMT can be used to treat autoimmune diseases such as RA, Crohn's disease and ulcerative colitis (UC), whereas autoimmune diseases such as Graves' disease and ITP have been transferred from donors to recipients by BMT. Based on these findings, we have proposed that autoimmune diseases are "stem cell disorders". To elucidate the difierences between normal and abnormal HSCs, we have very recently established a new method for purifying pluripotent HSCs (P-HSCs). Using P-HSCs purified by our method, we have compared normal and abnormal P-HSCs, and found that qualitative differences exist between them both <I>in vivo</I> and <I>in vitro</I>; although normal P-HSCs do not readily proliferate in major histocompatibility complex (MHC) -incompatible microenvironments, abnormal P-HSCs show a marked proliferative response even in the allogeneic environments. Abnormal P-HSCs are thus more "resilient" than normal P-HSCs.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 30(1), 3-12, 1997-02-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

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各種コード

  • NII論文ID(NAID)
    10008605891
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00445991
  • データ提供元
    CJP書誌  J-STAGE 
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