Lowering Extracellular pH Raises Intracellular Calcium in Cultured Rat Astrocytes

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著者

    • NAGAOKA Takanori
    • Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine
    • MASUDA Atsushi
    • Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine
    • TAKAMATSU Tetsuro
    • Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine

抄録

The relationship between extracellular pH and intracellular calcium concentration ([Ca<SUP>2+</SUP>] <SUB>1</SUB>) in primary culture of neonatal rat astrocytes with Ca<SUP>2+</SUP>-indicator dye indo-1/acetoxymethyl ester and a confocal microscope was investigated. In 65 of 86 astrocytes studied, lowering extracellular pH by changing the perfusate solution from pH 7.4 to 6.4 was followed by increases in [Ca<SUP>2+</SUP>] <SUB>1</SUB> in cytoplasm. The increases in [Ca<SUP>2+</SUP>] <SUB>1</SUB> were seen on stimulation and/or during reperfusion. Of all the cells, 45.4% showed a transient pattern and 30.2% manifested a sustained pattern. The results suggest that a short interval but excessive acidic stimulation may be one of the signals that raises [Ca<SUP>2+</SUP>] <SUB>1</SUB> in a certain population of cerebral astrocytes.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 30(2), 221-225, 1997-04-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

参考文献:  34件中 1-34件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008606711
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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