Enzyme Histochemistry on Normal and Pathological Human Thymic Tissues

この論文にアクセスする

この論文をさがす

著者

    • REZZANI Rita
    • Department of Biomedical Sciences and Biotechnology, University of Brescia
    • RODELLA Luigi
    • Department of Biomedical Sciences and Biotechnology, University of Brescia
    • BIANCHI Rossella
    • Department of Biomedical Sciences and Biotechnology, University of Brescia

抄録

The human thymuses, the well differentiated carcinoma, the thymoma with spindle epithelial cells and the undifferentiated thymoma have been examined by histochemical techniques [lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), acid phosphatase (AcP), alkaline phosphatase (ALP) and dihydrofolate dehydrogenase (DHFR)] to study the metabolic changes due to the pathological conditions in the epithelial cells (EPCs) and accessory cells. In all three different types of studied thymomas the EPCs showed a more intense LDH and SDH positivity than in normal thymus. These data indicate a possible damage of respiratory chain energy-coupling mechanism. The EPCs presented a different pattern (negative or very strong) of ALP and AcP positivity both in normal and pathological thymuses. These results suggest that the EPCs are a heterogenous population presenting a variety of functional activities both in normal and pathological conditions. The macrophages showed a different pattern (very weak, weak and moderate) in dehydrogenase and in hydrolytic enzymes both in normal and tumour cells. The macrophages were uniformly distributed throughout the thymoma but it is interesting to note that in the well differentiated thymomas these cells were localized in high number only around the neoplastic nodules that were proliferating. These findings suggest that the macrophages are important for defending the organism against the formation of new neoplastic nodules.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 30(4), 323-329, 1997-08-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

参考文献:  19件中 1-19件 を表示

各種コード

  • NII論文ID(NAID)
    10008607012
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  J-STAGE 
ページトップへ