Novel Ca^<2+>-binding S100 Proteins, Glial Fibrillary Acidic Protein and Tenascin in Chondro-osseous Tumors

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著者

    • MURAMATSU Yasunori
    • Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
    • KAMEGAI Akihide
    • Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
    • YAN Zhang
    • Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
    • SHRESTHA Prashanta
    • Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
    • TAKAI Yoshiaki
    • Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
    • MORI Masahiko
    • Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
    • ILG Evelyn
    • Department of Pediatrics, Division of Clinical Chemistry, University of Zurich
    • SCHAFER Beat W.
    • Department of Pediatrics, Division of Clinical Chemistry, University of Zurich
    • Heizmann Claus W.
    • Department of Pediatrics, Division of Clinical Chemistry, University of Zurich

抄録

The expression of Novel Ca<I>2+</I>-binding pro teins S100A1, S100A2, S100A4, S100A6 and S100B; an intermediate filament protein, glial fibrillary acidic protein (GFAP); and an extracellular matrix glycoprotein, tenascin were evaluated in chondro-osseous tumors. The tumor specimens obtained from surgery and routinely processed for paraffin embedding were evaluated. The tumors were histologically diagnosed as chondroma (n=2), osteoma (n=2), chondrosarcoma (n=3), osteosarcoma (n=6) and Ewing's sarcoma (n=2). Chondrocytes or chondrometaplastic cells in both benign and malignant tumors as well as undifferentiated round, spindle and elongated cells in chondrosarcoma and osteosarcoma showed an intense immunoreactivity for S100B and occasionally for S100A6, S100A1 and S100A4 but not for S100A2. The intensity of immunostaining for osteosarcoma was less intense than that for chondrosarcoma. S100B reactive cells were also reactive for GFAP, although the intensity of staining was less intense for GFAP. Reaction products for tenascin was seen in the matrix of neoplastic cartilage in chondroma and chondrosarcoma, and uncalcified osseous matrix in osteoma and osteosar coma, and the immunoreactive areas of tenascin usually coincided with intensely reactive cells for S100B in neoplastic chondroid tissue. The results reasonably allowed to conclude that S100B may be a potential marker for the identification of chondroid cells in neoplastic lesions and the S100B containing cells may express GFAP and may be associated with an enhanced expression of tenascin in the tumor matrix, the functional significance of which is under investigation.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 30(5), 445-453, 1997-10-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

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各種コード

  • NII論文ID(NAID)
    10008607416
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  J-STAGE 
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