A Light Microscopic Radioautographic Study on Protein Synthesis in Pulmonary Cells of Aging Mice

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著者

    • SUN Lin
    • Department of Anatomy and Cell Biology, Shinshu University School of Medicine
    • GAO Fulu
    • Department of Anatomy and Cell Biology, Shinshu University School of Medicine
    • NAGATA Tetsuji
    • Department of Anatomy and Cell Biology, Shinshu University School of Medicine

抄録

In the present study we first investigated the changes in protein synthesis of respective cell types of mouse pulmonary alveoli from 16 days of fetal life to senility (postnatal 22 months) by using <SUP>3</SUP>H-leucine light microscopic radioautography. The results revealed that the protein syntheses in type I epithelial cells, type II epithelial cells, interstitial cells and endothelial cells in the mouse lung changed due to aging. The protein synthesis of type I epithelial cells was the highest on postnatal day 1, increased again at 1 week after birth, and then decreased gradually to 22 months after birth with aging. The protein syntheses of type II epithelial cells, interstitial cells and endothelial cells reached the highest level on fetal day 16, declined progressively with age, and increased again at postnatal 1 week, and then decreased gradually from 2 weeks to senility. Our results suggest that the decreases in protein synthesis are correlated with the decremental changes in DNA and RNA synthesis in the lung with aging.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 30(5), 463-470, 1997-10-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

参考文献:  44件中 1-44件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008607501
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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