A Light Microscopic Radioautographic Study on Protein Synthesis in Pulmonary Cells of Aging Mice.

• Sun Lin

  Department of Anatomy and Cell Biology, Shinshu University School of Medicine

• Gao Fulu

  Department of Anatomy and Cell Biology, Shinshu University School of Medicine

• Nagata Tetsuji

  Department of Anatomy and Cell Biology, Shinshu University School of Medicine

抄録

In the present study we first investigated the changes in protein synthesis of respective cell types of mouse pulmonary alveoli from 16 days of fetal life to senility (postnatal 22 months) by using ³H-leucine light microscopic radioautography. The results revealed that the protein syntheses in type I epithelial cells, type II epithelial cells, interstitial cells and endothelial cells in the mouse lung changed due to aging. The protein synthesis of type I epithelial cells was the highest on postnatal day 1, increased again at 1 week after birth, and then decreased gradually to 22 months after birth with aging. The protein syntheses of type II epithelial cells, interstitial cells and endothelial cells reached the highest level on fetal day 16, declined progressively with age, and increased again at postnatal 1 week, and then decreased gradually from 2 weeks to senility. Our results suggest that the decreases in protein synthesis are correlated with the decremental changes in DNA and RNA synthesis in the lung with aging.

収録刊行物

• Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ

  Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 30 (5/6), 463-470, 1997

  日本組織細胞化学会

キーワード

• Protein synthesis
• Aging
• Lung
• Radioautography
• Mice

詳細情報

• CRID: 1390001204863327488
• NII論文ID: 10008607501
• NII書誌ID: AA00508022
• DOI: 10.1267/ahc.30.463
• ISSN: 13475800
• ISSN: 00445991
• ISSN: http://id.crossref.org/issn/00445991
• Web Site: http://www.jstage.jst.go.jp/article/ahc1968/30/5-6/30_5-6_463/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1998187675
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可