Human Epithelial Related Antigen (hERA) in Salivary Glands and Their Tumors: Immunohistochemical Observations.

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  • Yamada Kazuto
    Department of Oral & Maxillofacial Surgery, Asahi University School of Dentistry
  • Kudeken Wataru
    Department of Oral & Maxillofacial Surgery, Asahi University School of Dentistry
  • Muramatsu Yasunori
    Department of Oral & Maxillofacial Surgery, Asahi University School of Dentistry
  • Sumitomo Shinichiro
    Department of Oral & Maxillofacial Surgery, Asahi University School of Dentistry
  • Takai Yoshiaki
    Department of Oral & Maxillofacial Surgery, Asahi University School of Dentistry
  • Mori Masahiko
    Department of Oral & Maxillofacial Surgery, Asahi University School of Dentistry

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The expression of human epithelial related antigen (hERA), a 40 kD transmembrane glycoprotein assigned to one of the small cell lung cancer antigen was evaluated in normal salivary glands and their tumors using immunohistochemical methods.<BR>In normal salivary gland acini, hERA was seen in lateral borders and basal plasma membrane of serous cells of the parotid and submandibular glands and in the basal layer of mucous cells of the sublingual and minor oral glands, the luminally projecting cell membrane being consistently unreactive. In ductal segments, hERA was seen in basal infoldings and lateral borders of striated duct cells, excretory ducts or interlobular ducts and the ductal basal cells in particular, were devoid of hERA immunostaining.<BR>Salivary pleomorphic adenoma showed luminal borders of tubulo-ductal structures immunoreactive for hERA whereas the nonluminal or the neoplastic myoepithelial cells were consistently unreactive. A similar pattern of immunoreactivity was observed in Warthin's tumor where lateral borders of luminally located tall columnar tumor cells showed reaction products whereas the basal cells were unreactive. Mucoepidermoid carcinoma showed hERA in epidermoid and intermediate tumor cells, but not in mucous secreting cells. In adenoid cystic carcinoma reaction product for hERA was seen in a limited number of lumen-lining cells and again the non-luminally located neoplastic myoepithelial cells were unreactive. The results of the present study suggest that hERA may be a useful marker to detect luminal cell components in salivary tumor and, apart from the neoplastic myoepithelial cells or their counterparts, these luminally located cells may have a potential implication in salivary gland tumorigenesis.

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