GLUT1 Glucose Transporter in the Lactating Mammary Gland in the Rat.

DOI Web Site 被引用文献3件 参考文献29件
  • Takata Kuniaki
    Laboratory of Molecular and Cellular Morphology, Institute for Molecular and Cellular Regulation. Gunma University
  • Fujikura Keiko
    Laboratory of Molecular and Cellular Morphology, Institute for Molecular and Cellular Regulation. Gunma University
  • Suzuki Masakazu
    Laboratory of Molecular and Cellular Morphology, Institute for Molecular and Cellular Regulation. Gunma University
  • Suzuki Takeshi
    Laboratory of Molecular and Cellular Morphology, Institute for Molecular and Cellular Regulation. Gunma University
  • Hirano Hiroshi
    Department of Anatomy, Kyorin University School of Medicine

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Localization of facilitated-diffusion glucose transporter GLUT1 was examined in the rat mammary gland by immunofluorescence microscopy and immunoperoxidase electron microscopy. Secretory epithelial cells of acini were enriched with GLUT1, which was localized to the basolateral plasma membrane. Apical plasma membrane and cytoplasmic organelles including the Golgi apparatus were negative for GLUT1. In addition to acini, abundant GLUT1 was found in the perineurium of nerve fiber bundles, which is a site of blood-nerve barriers. GLUT1 in the basolateral membrane of secretory epithelial cells seems to serve as machinery to take up glucose into the cell for milk synthesis and secretion.

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