Different Actions of Chinese Traditional Medicines against Adriamycin-induced Cytotoxicity

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著者

    • NODA Toru
    • Department of Anatomy, Faculty of Medicine, Kyoto Unviersity
    • YU Xiang Min
    • Department of Anatomy, Faculty of Medicine, Kyoto Unviersity
    • OGAWA Kazuo
    • Department of Anatomy, Faculty of Medicine, Kyoto Unviersity

抄録

Prophylactic and curative effects of two tradi tional Chinese medicines, Rikkunshito (TJ-43) and Shigyakusan (TJ-35), against adriamycin (ADM) -induced cytotoxicity were studied in gastric epithelium and cardiac ventricular myocytes based on histochemical analysis of mitochondrial cytochrome oxidase (COX) activity. Oral administration of TJ-43 and TJ-35 prior to the injection of ADM preserved the COX activities both in gastric epithelium and cardiocytes to the normal levels. However, post-treatment with both drugs after ADM injection showed different enzyme activities between TJ-43-and TJ-35-treated groups. In both tissues, post-treatment of TJ-43 retained significant enzyme activity, whereas the enzyme activity of the TJ-35-treated groups was comparable or lower than that in ADM-injected controls without drug treatment. Although both TJ-43 and TJ-35 scavenge free radicals, no curative effect of TJ-35 against ADM-induced cytotoxicity was observed.

収録刊行物

  • Acta histochemica et cytochemica

    Acta histochemica et cytochemica 30(5), 661-663, 1997-10-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

参考文献:  6件中 1-6件 を表示

各種コード

  • NII論文ID(NAID)
    10008608196
  • NII書誌ID(NCID)
    AA00508022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00445991
  • データ提供元
    CJP書誌  J-STAGE 
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