Innovative drug discovery in Japan: past, present and future problems

• Kato Ryuichi

  Department of Pharmacology, School of Medicine, Keio University

Bibliographic Information

Other Title

• 日本における創薬：過去と現状から将来への課題

Abstract

Although many new chemical entities have been put into therapeutic drug market in Japan, innovative drug discovery from Japanese pharmaceutical industries is poor.<BR> Author divided innovative drug discovery sciences into two phases: The first phase consist of discovery of seed compound and development of lead compound from seed compound. The second phase consist of development of therapeutic drug from lead compound. Strategic drug metabolism studies and toxicological studies are indispensable for rescue of toxicologically and pharmacokinetically difficult compounds. The author emphasize the importance of development of sciences for the second phase for innovative drug discovery. The author also pointed out the necessity of colaborations among universities, industries and regulatory agent for the promotion of innovative drug discovery.

Journal

• Folia Pharmacologica Japonica

  Folia Pharmacologica Japonica 106 (supplement), 20-22, 1995

  The Japanese Pharmacological Society

Keywords

• Pharmacology

Details

• CRID: 1390001204270802560
• NII Article ID: 10008631181
• NII Book ID: AN00198335
• DOI: 10.1254/fpj.106.supplement_20
• ISSN: 13478397
• ISSN: 00155691
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed