血管平滑筋シグナルと創薬 Cell signaling and vasodilator drugs
Vascular smooth muscle contraction is regulated by various factors including membrane potential, receptor-linked signal transduction pathways, cytoplasmic Ca concentration, and Ca sensitivity of contractile elements. Vasodilator drugs are acting on either of these mechanisms to inhibit contraction. In 1922, 338 vasodilator drugs were sold in Japan. Among them, there were 67 Ca antagonists and one K channel opener. Mechanisms of action of other 270 drugs are not clarified yet (although 84 drugs increase cyclic AMP and 36 drugs increase cyclic GMP, mechanisms of action of these cyclic nucleotides are still ambiguous). To elucidate the mechanisms of vasodilator drugs will help not only to clarify the regulation mechanisms of smooth muscle contraction but also to develop new vasodilator drugs with novel sites of action including Ca sensitivity.
日本薬理学雑誌 106, 50-55, 1995-09-01