α<SUB>2</SUB>ヘテロ受容体を介するセロトニン遊離調節機構の脱感作

• 吉岡 充弘

  北海道大学医学部第一薬理学教室

• 松本 真知子

  北海道大学医学部第一薬理学教室

• 富樫 広子

  北海道大学医学部第一薬理学教室

• 齋藤 秀哉

  北海道大学医学部第一薬理学教室

書誌事項

タイトル別名

• Subsensitivity of the presynaptic α<SUB>2</SUB>-adrenoceptors (heteroreceptors) that regulate serotonergic neuronal function.

抄録

In vivo microdialysis was used to measure the effects of long-term treatment of rats with desipramine upon the regulation by α₂-adrenoceptors of serotonin (5-HT) release from the serotonergic neurons in the hippocampus. Extracellular levels of 5-HT were estimated by assaying its concentrations in the perfusate using HPLC-ECD. When the α₂-adrenoceptor agonist brimonidine was added to the perfusion solution, the K⁺-evoked 5-HT release was significantly inhibited in a concentration-dependent manner. Treatment with pertussis toxin did not alter the K⁺-evoked release of 5-HT but abolished the inhibitory effect of brimonidine. Long-term desipramine treatment significantly reduced the inhibitory effect of brimonidine upon the K⁺-evoked 5-HT release, and both the 5-HT content of the hippocampus and the basal 5-HT concentration in the dialysate were significantly increased. The present study suggests that long-term administration of desipramine causes a functional subsensitivity of the presynaptic α₂-adrenoceptors that regulate serotonergic neuronal function in the rat hippocampus. It also supports the concept that changes in the sensitivity of α₂-adrenoceptors that regulate neurotransmitter release play an important role in the mechanism of antidepressant drug action.

収録刊行物

• 日本薬理学雑誌

  日本薬理学雑誌 106 (supplement), 157-161, 1995

  公益社団法人 日本薬理学会

キーワード

• Pharmacology

詳細情報

• CRID: 1390282679247484160
• NII論文ID: 10008631406
• NII書誌ID: AN00198335
• DOI: 10.1254/fpj.106.supplement_157
• ISSN: 13478397
• ISSN: 00155691
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可