Cardiovascular Effects of Novel Azulene-1-Carboxamidine Derivative, HNS-32

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  • 新規合成アズレン-1-カルボキサミジン誘導体HNS-32の心血管におよぼす作用

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Abstract

A novel azulene-1-carboxamidine delivative (HNS-32) was synthesized and its cardiovascular effects were assessed using well-established isolated, blood-perfused, canine sinoatrial node, papillary muscle and atrioventricular node preparations. The yields of HNS-32 was about 44 % of the amount expected from the chemical equation. The found, chemical structure, molecular weight and color of HNS-32 were C24H30N3, N1-dimethyl-N2-(2-picolino) azulene-l-carboxamidine, 360.242 and dark blue, respectively. HNS-32 suppressed the sinus nodal automaticity and contractile force, while increased the coronary blood flow and AH and HV intervals (n=5). The drug shortened the repolarization phase of monophasic action potentials of right ventricle (n=4). The vasodilator effect was 3-10 times more potent than each cardiac effect. The pharmacological properties resemble those of calcium channel blocking drugs with modest sodium channel inhibition and potassium channel opening. HNS-32 may become a new drug with unique chemical structure that affects cardiovascular system.

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Details 詳細情報について

  • CRID
    1390001204270798848
  • NII Article ID
    10008631449
  • NII Book ID
    AN00198335
  • DOI
    10.1254/fpj.106.supplement_192
  • ISSN
    13478397
    00155691
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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