拘束ストレスによるラット脳内β-アドレナリン受容体の変動と高血圧 IMMOBILIZATION STRESS-INDUCED HYPERTENSION AND DOWN-REGULATION OF CENTRAL β-ADRENOCEPTORS IN RATS

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Effects of chronic treatment with propranolol or atenolol on stress-induced changes in blood pressure and cerebral β-adrenoceptors were examined in rats. Immobilization stress (2 h daily for 2 weeks) induced a moderate elevation of blood pressure and downregulation of cerebral β-adrenoceptors. Chronic administration of propranolol (5 mg•kg<SUP>-1</SUP>) or atenolol (5 mg•kg<SUP>-1</SUP>) inhibited stress-induced hypertension. Propranolol and atenolol increased the density of cerebral β-adrenoceptors and inhibited the downregulation induced by stress. These results suggest that the antihypertensive action of propranolol and atenolol may be partly associated with the inhibition of stress-activated central β-adrenoceptor transmission.

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  • 日本薬理学雑誌

    日本薬理学雑誌 106, 227-230, 1995-09-01

    公益社団法人 日本薬理学会

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