Sibling cases of nephritis resembling membranoproliferative glomerulonephritis.

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  • UEDA Hideki
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine
  • ISIMURA Eiji
    Department of Nephrology, Osaka City University Graduate School of Medicine
  • OKUNO Senji
    Shirasagi Hospital Kidney Center
  • MAEKAWA Kiyoshi
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine
  • IZUMOTANI Tsuyoshi
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine
  • KIM Masao
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine
  • MATSUMOTO Naoki
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine
  • FUKUMOTO Shinya
    Department of Pathology, Osaka City University Graduate School of Medicine
  • IMANISHI Yasuo
    Department of Pathology, Osaka City University Graduate School of Medicine
  • EMOTO Masanori
    Department of Pathology, Osaka City University Graduate School of Medicine
  • SHOJI Tetsuo
    Department of Pathology, Osaka City University Graduate School of Medicine
  • WANIBUCHI Hideki
    Department of Pathology, Osaka City University Graduate School of Medicine
  • INABA Masaaki
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine
  • NISHIZAWA Yoshiki

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Other Title
  • 内皮下沈着物を認め膜性増殖性糸球体腎炎様の病変を呈した家族性糸球体腎炎の兄弟発症例

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Abstract

We have experienced rare cases of membranoproliferative glomerulonephritis (MPGN)-like nephritis, which was seen in siblings. Both the brothers had asymptomatic hematuria and proteinuria at an age before 10, 7 and 4 years old, respectively. Renal biopsy revealed proliferative glomerulonephritis, resembling MPGN type III. The family history showed that their father and grandfather suffered from end-stage renal disease, suggesting that MPGN seen in the present sibling cases is hereditary. A review of the literature revealed that familial MPGN is rare, that most of the cases have urinary abnormalities at an age of less than 10 years. and that male preponderance is seen in familial MPGN.

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