Ca^2+ Depletion Facilitates Taurine Release in Cultured Rat Astrocytes

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抄録

Removal of external Ca<SUP>2+</SUP> facilitated endogenous taurine release in cultured rat astrocyies. The stimulated release was not affected by furosemide, sucrose, tetrodotoxin and 3, 4-dichlorobenzamil, but partially inhibited by nifedipine. Omission of external Na+ increased basal taurine release, and the effects of Na<SUP>+</SUP> removal and Ca<SUP>2+</SUP> depletion on the release were additive. The Na<SUP>+</SUP>-free condition did not affect Ca<SUP>2+</SUP> paradox-induced cell death in astrocyies. These findings suggest that Ca<SUP>2+</SUP> depletion facilitates taurine release in a mechanism independent of volume and the Na+ gradient and that the release is not involved in Ca<SUP>2+</SUP> paradox-induced delayed cell toxicity in astrocytes.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 72(1), 75-78, 1996-09-01

    The Japanese Pharmacological Society

参考文献:  12件中 1-12件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008675744
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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