Cellular and Molecular Aspects of Monoamine Neurotransmitter Transporters.

DOI Web Site Web Site Web Site PubMed 被引用文献7件 参考文献218件
  • Kitayama Shigeo
    <I>Department of Pharmacology, Hiroshima University School of Dentistry</I>
  • Dohi Toshihiro
    <I>Department of Pharmacology, Hiroshima University School of Dentistry</I>

書誌事項

タイトル別名
  • Cellular and Molecular Aspects of Monoa

この論文をさがす

抄録

Neurotransmitter transporters terminate synaptic neurotransmission by accumulating neurotransmitters once again after release in a sodium- and chloride-dependent fashion. The availability of the cloned neurotransmitter transporters has allowed investigation into the roles of these transporters in neuronal function. Molecular biological and protein engineering studies including in vitro site-directed mutagenesis, chimera formation of several transporter clones, or epitope-tagging various regions of transporter proteins, have revealed the topology and functionally mapped the transporter proteins. Monoamine neurotransmitter transporters such as those for dopamine, norepinephrine and serotonin are of interest, since they are a target of drugs of abuse and are involved in neuronal disorders including Parkinson''s disease and depression. Therefore, elucidating the molecular basis of these transporters may clarify these problems and help develop treatments with which to combat these disorders and drug abuse.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 72 (3), 195-208, 1996

    公益社団法人 日本薬理学会

被引用文献 (7)*注記

もっと見る

参考文献 (218)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ