Characterization of Dextran Sulfate-Induced Guinea Pig Tracheal Plasma Extravasation

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We examined the effect of dextran sulfate on guinea pig tracheal vascular permeability. I. v. injection of dextran sulfate (10-100 mg/kg) with captopril (1 mg/kg) induced guinea pig tracheal plasma extravasation. The i. v. administration of bradykinin (0.8-8 μg/kg) with captopril (1 mg/kg) also induced plasma extravasation. Bradykinin B<SUB>2</SUB> antagonists, D-Arg[Hyp<SUP>3</SUP>-Thi<SUP>5</SUP>-D-Tic<SUP>7</SUP>-Tic<SUP>8</SUP>]-bradykinin (NPC 16731) and D-Arg[Hyp<SUP>3</SUP>-Thi<SUP>5</SUP>-D-Tic<SUP>7</SUP>-0ic<SUP>8</SUP>]-bradykinin (Hoe 140), reduced both dextran sulfate (32 mg/kg)- and bradykinin (2.5 μg/kg)-induced tracheal plasma extravasation in a dose-dependent manner. However, a cyclooxygenase inhibitor, indomethacin (1 mg/kg), and a neurokinin antagonist, {<I>N</I>-[<I>N</I><SUP>2</SUP>-[<I>N</I>-[<I>N</I>-[<I>N</I>-[2, 3-didehydro-<I>N</I>-methyl-<I>N</I>-[<I>N</I>-[3-(2-pentylphenyl)-propionyl]-L-threonyl] tyrosyl-L-Ieucynyl]-D-phenylalanyl]-L-allo-threonyl]-L-asparaginyl]-L-serine-ϒ-lactone} (FK 224) (1 mg/kg), had no effect on tracheal plasma extravasation induced by dextran sulfate and bradykinin. Dextran sulfate (32 mg/kg) with captopril (1 mg/kg) greatly increased the bradykinin level in guinea pig plasma. This evidence suggests that dextran sulfate releases bradykinin in guinea pig plasma and causes guinea pig tracheal plasma extravasation via the activation of bradykinin B<SUB>2</SUB>-receptors.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 72(3), 217-221, 1996-11-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008675926
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4080031
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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