Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration

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  • Nitta Atsumi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine Laboratory of Molecular Biology, Gifu Pharmaceutical University
  • Fukuta Taneo
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
  • Hasegawa Takaaki
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
  • Nabeshima Toshitaka
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine

書誌事項

タイトル別名
  • Continuous Infusion of .BETA.-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration.
  • Continuous Infusion of ベータ Amyloid Prot
  • Continuous infusion of β-amyloid protein into cerebral ventricle induces learning impairment and neuronal and morphological degeneration

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抄録

To investigate the toxicity of β-amyloid protein, a component of the senile plaques in Alzheimer''s disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in β-amyloid protein-treated rats were impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after the cessation of the infusion. However, the learning impairment was recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after the cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Furthermore, β-amyloid protein altered the staining in the nuclei of hippocampal cells for only 2 weeks after the cessation. These results suggest that β-amyloid protein produces some damage in the central nervous system in vivo.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 73 (1), 51-57, 1997

    公益社団法人 日本薬理学会

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