Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration

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To investigate the toxicity of β-amyloid protein, a component of the senile plaques in Alzheimer''s disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in β-amyloid protein-treated rats were impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after the cessation of the infusion. However, the learning impairment was recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after the cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Furthermore, β-amyloid protein altered the staining in the nuclei of hippocampal cells for only 2 weeks after the cessation. These results suggest that β-amyloid protein produces some damage in the central nervous system in vivo.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 73(1), 51-57, 1997-01-01

    The Japanese Pharmacological Society

参考文献:  19件中 1-19件 を表示

被引用文献:  9件中 1-9件 を表示

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各種コード

  • NII論文ID(NAID)
    10008676860
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4131795
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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