Protective Effect of Ifenprodil against Glucose Deprivation-Induced Damage in Cultured Rat Hippocampal Neurons

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抄録

When hippocampal cultures were deprived of glucose, massive release of lactate dehydrogenase (LDH), an indicator of neuronal death, occurred 24 hr following the onset of hypoglycemic insult via N-methyl-D-aspartate (NMDA)-type glutamate receptor activation. Ifenprodil (0.1 and 1 M)significantly inhibited LDH release, which was antagonized by polyamines. These results suggest that ifenprodil protects neurons from glucose deprivation by antagonizing the effects of glutamate via selective interaction with polyamine modulatory sites on the NMDA receptor complex. The observed phenomenon further indicate that ifenprodil might be used prophylactically against neuronal death induced by excitotoxic disorders.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 73(1), 97-100, 1997-01-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008677004
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4131800
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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