Dexamethasone Increases .BETA.2-Adrenoceptor-Regulated Phosphatidylcholine Secretion in Rat Alveolar Type II Cells.

• Isohama Yoichiro

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Kumanda Yukie

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Tanaka Katsuyuki

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Kai Hirofumi

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Takahama Kazuo

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Miyata Takeshi

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

Bibliographic Information

Other Title

• Dexamethasone Increases β2-Adrenoceptor-Regulated Phosphatidylcholine Secretion in Rat Alveolar Type 2 Cells
• Dexamethasone Increases ベータ2 Adrenocept

Abstract

Insufficient production of pulmonary surfactant in alveolar type II cells is relevant to many lung diseases. To cure its deficiency, glucocorticoid is commonly used in clinical areas. In the present study, we investigated the effect of dexamethasone on the secretion of phosphatidylcholine, a major phospholipid of pulmonary surfactant, in a primary culture of rat alveolar type II cells. Dexamethasone had no effect on the basal secretion rate of phosphatidylcholine. Dexamethasone augmented both the phosphatidylcholine secretion and the cyclic AMP formation increased by terbutaline. Furthermore, dexamethasone increased the number of β-adrenoceptors and mRNA expression of β₂-adrenoceptors in type II cells. These findings indicate that dexamethasone increases pulmonary surfactant secretion through an enhancement of β₂-adrenoceptor gene expression.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 73 (2), 163-169, 1997

  The Japanese Pharmacological Society

Keywords

• Alveolar type II cell
• Glucocorticoid
• β-Adrenoceptor
• Pulmonary surfactant
• RNase protection assay

Details

• CRID: 1390282679263670400
• NII Article ID: 10008677223
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.73.163
• COI: 1:CAS:528:DyaK2sXhsVWmt78%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• NDL BIB ID: 4153691
• PubMed: 9074950
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4153691
• Web Site: https://search.jamas.or.jp/link/ui/1997123743
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed