Regional Hemodynamic Effects of Candesartan Cilexetil (TCV : 116),an Angiotensin II AT_1 : Receptor Antagonist,in Conscious Spontaneously Hypertensive Rats

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著者

    • Wada Takeo WADA Takeo
    • Pharmaceutical Research Laboratories II,Phoarmaceutical Research Division,Takeda Chemical Industries,Ltd.
    • OJIMA Nami
    • Pharmaceutical Research Laboratories II,Phoarmaceutical Research Division,Takeda Chemical Industries,Ltd.
    • INADA Yoshiyuki
    • Pharmaceutical Research Laboratories II,Phoarmaceutical Research Division,Takeda Chemical Industries,Ltd.

抄録

The regional hemodynamic effects of candesartan cilexetil (TCV-116), a selective angiotensin II AT<SUB>1</SUB>-receptor antagonist, and enalapril, an angiotensin-converting enzyme inhibitor, were compared in conscious spontaneously hypertensive rats (SHR). A 7-day repeated administration study was carried out. TCV-116 (1 mg/kg, p.o.)and enalapril (10 mg/kg, p.o.)reduced blood pressure to the same extent 5 hr after administration on the 1st and the 7th day. At these points, the cardiac index and organ or tissue blood flow were measured by the non-radioactive colored dye-extraction microsphere technique. Repeated administration of TCV-116, and single and repeated administration of enalapril significantly increased renal blood flow without any changes in the cardiac index. TCV-116 and enalapril also tended to increase splanchnic blood flow following the 1st dose but not the 7th dose. No significant changes in blood flow were observed in the brain, heart, adrenal, skin and skeletal muscle. These results suggest that the antihypertensive effects of TCV-116 and enalapril are attributable to the systemic reduction of vascular resistance caused by the dilatation of blood vessels. These hemodynamic effects of TCV-116, like those of enalapril, may be beneficial in the treatment of hypertension.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 73(3), 185-190, 1997-03-01

    The Japanese Pharmacological Society

参考文献:  27件中 1-27件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008677302
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4196912
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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