Methamphetamine-Induced Sensitization of Dopamine Release via a Metabotropic Glutamate Receptor Mediated Pathway in Rat Striatal Slices.

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  • Arai Ikumi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
  • Shimazoe Takao
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
  • Shibata Shigenobu
    Department of Pharmacology, School of Human Sciences, Waseda University
  • Inoue Hirotaka
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
  • Yoshimatsu Akiko
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62
  • Watanabe Shigenori
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62

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  • Methamphetamine-Induced Sensitization o

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Abstract

We studied the roles of metabotropic glutamate receptors in methamphetamine (MAP)induced sensitization of dopamine (DA) release from striatal slices. Rats were first treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days. After a 6-day withdrawal, DA release from striatal slices evoked by ±-1-aminocyclopentane-trans-1, 3-dicarboxylic acid (trans-ACPD)was measured. transACPD-induced DA release was significantly enhanced in MAP-sensitized rats, but the inactive form of trans-ACPD (1R, 3S-ACPD) did not enhance DA release. The active form of trans-ACPD (1S, 3R-ACPD) (0.1 mM) -evoked DA release was attenuated by treatment with 0.4 MM RS-α-methyl-4-carboxyphenylglycine, a metabotropic glutamate receptor antagonist. The present results suggest that metabotropic glutamate receptors play an important role in expression of MAP-induced sensitization.

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