Persistence of Cyclopiazonic Acid-Induced Endothelium-Dependent Vasodilatation in Spontaneously Hypertensive and Streptozotocin-Induced Diabetic Rats.

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  • Kamata Katsuo
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
  • Hayashi Tsuyoshi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
  • Umeda Fujio
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

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タイトル別名
  • Persistence of Cyclopiazonic Acid-Induc

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抄録

We recently reported that cyclopiazonic acid (CPA)r eleases a novel endothelium-derived relaxing factor that is not prostacyclin, nitric oxide or endothelium-derived hyperpolarizing factor in rat mesenteric arterial bed. The acetylcholine-induced vasodilatation of the isolated mesenteric bed in spontaneously hypertensive rats (SHR) was not different from that in Wistar Kyoto rats (WKY), but it was significantly smaller in streptozotocin (STZ) -induced diabetic rats than in age-matched controls. The CPAinduced vasodilatation was not affected in SHR or in STZ-induced diabetic rats. These results suggest that the CPA-induced endothelium-dependent vasodilatation is resistant to the effects of diabetes.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 73 (3), 247-250, 1997

    公益社団法人 日本薬理学会

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