Persistence of Cyclopiazonic Acid : Induced Endothelium : Dependent Vasodilatation in Spontaneously Hypertensive and Streptozotocin : Induced Diabetic Rats

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We recently reported that cyclopiazonic acid (CPA)r eleases a novel endothelium-derived relaxing factor that is not prostacyclin, nitric oxide or endothelium-derived hyperpolarizing factor in rat mesenteric arterial bed. The acetylcholine-induced vasodilatation of the isolated mesenteric bed in spontaneously hypertensive rats (SHR) was not different from that in Wistar Kyoto rats (WKY), but it was significantly smaller in streptozotocin (STZ) -induced diabetic rats than in age-matched controls. The CPAinduced vasodilatation was not affected in SHR or in STZ-induced diabetic rats. These results suggest that the CPA-induced endothelium-dependent vasodilatation is resistant to the effects of diabetes.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 73(3), 247-250, 1997-03-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008677516
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4196920
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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