Application of Physiologically Active Substances Isolated from Natural Resources to Pharmacological Studies

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Numerous neurotoxins that alter Na<SUP>+</SUP>-channel function have been shown to be useful tools for characterizing Na<SUP>+</SUP> channels. Polypeptide blockers of voltage-dependent K<SUP>+</SUP> channels (dendrotoxins, etc.) and Ca<SUP>2+</SUP> -activated K<SUP>+</SUP> channels (apamine, etc.) have been studied extensively by numerous investigators. Peptide toxins, calciseptine and ω-conotoxins have been attracting much attention as inhibitors of L-type and N-type Ca<SUP>2+</SUP> channels, respectively, while ω-conotoxins-MVIIC and ω-agatoxin IVA have been used as new types of Ca<SUP>2+</SUP> -channel blockers. Ryanodine and bromoeudistomin D analogues have been extensively used to elucidate Ca<SUP>2+</SUP> -release-channel functions and to purify its target protein. Polypeptide toxins (myotoxin α, etc.) and macrolides (FK 506, etc.) are useful Ca<SUP>2+</SUP> releasers with a novel mechanism, while natural products such as thapsigargin and gingerol have been used as modulators of Ca<SUP>2+</SUP> -pumping ATPase. Some modulators of the function of myosin (purealin, etc.) and actin (goniodomin A, etc.)have been demonstrated to be important chemical probes for understanding the physiological roles of the contractile proteins in structural changes and their interaction in muscle contraction. A large number of protein kinase inhibitors (staurosporine, etc.) and phosphatase inhibitors (okadaic acid, etc.)are widely used as first-choice reagents for studying protein phosphorylation. These natural products have become essential tools for studying the regulatory mechanism of cellular ion movements, muscle contraction and protein phosphorylation.

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  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 73(4), 263-289, 1997-04-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008677565
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00215198
  • NDL 記事登録ID
    4196924
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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