Enhancement of Interleukin-1- Mediated Autocrine Growth of Cultured Human Keratinocytes by Sho-saiko-to.
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- Matsumoto Yoshinari
- Department of Dermatology, Nagoya University, School of Medicine
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- Kato Masashi
- Department of Immunology, Nagoya University, School of Medicine
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- Tamada Yasuhiko
- Department of Dermatology, Aichi Medical University, Nagakute
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- Mori Hijiri
- Department of Dermatology, Nagoya University, School of Medicine
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- Ohashi Masaru
- Department of Dermatology, Nagoya University, School of Medicine
Bibliographic Information
- Other Title
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- Enhancement of Interleukin-1α Mediated Autocrine Growth of Cultured Human Keratinocytes by Sho-saiko-to
- Enhancement of Interleukin 1アルファ Mediat
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Abstract
We investigated the effects of Sho-saiko-to, the most commonly used herbal medicine in Japan, on the production of interleukin (IL)-la by cultured human epidermal keratinocytes. IL-lα production was significantly promoted by treatment with 100 or 500 μg/ml Sho-saiko-to for 24 or 48 hr. Expression of IL-lα receptors was the most markedly upregulated after treatment with 500 μg/ml Sho-saiko-to for 24 hr and with 100 or 500 μg/ml for 48 hr; these cells showed the characteristics of multilayered differentiated keratinocytes. The presence of an anti-IL-lα antibody during the treatment with 500 μg/ml of Sho-saiko-to for 24 or 48 hr or with 100 μg/ml for 48 hr significantly down-regulated the synthesis by the keratinocytes and induced damages in them. Keratinocytes treated with Sho-saiko-to might produce IL-lα and express IL-lα receptors. IL-lα may regulate the proliferation and differentiation of keratinocytes after Sho-saiko-to treatment. These findings suggest that Sho-saiko-to enhances the autocrine growth mediated by IL-lα.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 73 (4), 333-336, 1997
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679263758720
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- NII Article ID
- 10008677851
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2sXivVeisLg%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4196930
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- PubMed
- 9165370
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed