Cardioprotecvtive Effect of K-7259,a Novel Dlazep Derivative,against Ischemia-Reperfusion Damage in Isolated,Working Rat Hearts

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抄録

Global ischemia (15 min)followed by reperfusion (10, 20 or 30 min)was performed in isolated, working rat hearts. Ischemia depressed mechanical function, which was not restored by reperfusion of 20 min. Preischemic administration of K-7259 (<I>N, N''</I>-bis[4-(3, 4, 5-trimethoxyphenyl)butyl]homopiperazine dihydrochloride)(1, 5 or 10 μM)decreased the function before ischemia, but it attenuated the ischemia-induced dysfunction during reperfusion (20 min). Postischemic administration of K-7259 (10 μM)or dilazep (20 μM)also attenuated the ischemia-induced dysfunction during reperfusion (30 min). Ischemia-reperfusion (10 min)increased the tissue malondialdehyde level, and postischemic administration of K-7259 (10 μM)or dilazep (20 μM)attenuated the malondialdehyde accumulation. K-7259 has a cardioprotective effect when given either before or after ischemia.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 73(4), 365-369, 1997-04-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008677957
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4196936
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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