Inhibitory Effects of Talipexole and Pramipexole on MPTP-Induced Dopamine Reduction in the Striatum of C57BL/6N Mice.

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  • Kitamura Yoshihisa
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University Department of Neurobiology, Kyoto Pharmaceutical University
  • Kohno Yasuko
    Product Management Department, Marketing Division, Nippon Boehringer Ingelheim Co., Ltd.
  • Nakazawa Minako
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Nomura Yasuyuki
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University Department of Neuroscience, Research Institute for Oriental Medicine, Toyama Medical and Pharmaceutical University

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  • Inhibitory Effects of Talipexole and Pr

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We have investigated the effects of two novel antiparkinsonian drugs, talipexole (Domin®)and pramipexole, on MPTP-induced dopamine (DA)reduction in the striatum of C57BL/6N mice in comparison with those of bromocriptine. Fifteen days after MPTP treatment (25 mg/kg, i.p., given daily for 5 days), the DA content in the striatum was decreased to 40-60010 of the control value. Among the three dopamine receptor agonists, talipexole and pramipexole (1 mg/kg, i.p., once a day for 20 days)more significantly suppressed the MPTP-induced DA reduction in the striatum than bromocriptine (10 mg/kg, i.p., once a day for 20 days). Talipexole did not influence [3H]MPP+ uptake into striatal synaptosomes. These results suggest that talipexole and pramipexole have a protective effect against MPTP-induced DA reduction in the striatum of C57BL/6N mice.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 74 (1), 51-57, 1997

    公益社団法人 日本薬理学会

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