Intracisternal Injection of Opioids Induces Itch-Associated Response through μ-Opioid Receptors in Mice

• Tohda Chihiro

  Analytical Research Center for Ethnomedicines, Research Institute for Wakan-yaku, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• Yamaguchi Tomomi

  Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• Kuraishi Yasushi

  Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

書誌事項

タイトル別名

• Intracisternal Injection of Opioids Induces Itch-Associated Response through .MU.-Opioid Receptors in Mice.
• Intracisternal Injection of Opioids Ind
• Intracisternal injection of opioids induces itch-associated responses through μ-opioid receptors in mice
• Intracisternal injection of opioids induced itch-associated response through μ-opioid receptors in mice
• Intracisternal injection of opioids induces itch-associated response through μ-opiod receptors in mice

抄録

We examined whether opioids, especially morphine, would centrally elicit scratching in mice and determined some characteristics of the scratch-inducing action of opioids. When intracisternally (i.c.) injected, morphine (0.1 3 nmol/mouse) produced a dose-dependent increase in scratching of the face, but not of the ears, head and body trunk. When injected intradermally into the rostral part of the back, morphine (at most potent i.c. dose of 3 nmol/mouse or higher) did not increase the scratching of the injected site. Facial scratching of the mouse induced by i.c. injection of morphine (0.3 nmol/mouse) was almost abolished by distraction and by naloxone (1 mg/kg, s.c.). [D-Ala², N-Me-Phe⁴, GIy⁵-ol]Enkephalin (DAMGO)(0.03-2 nmol), but not [D-Pen^{2, 5}]enkephalin (DPDPE)and U-50, 488, dose-dependently elicited facial scratching by i.c. injection. These results suggest that morphine and DAMGO increased facial scratching, probably mediated by central opioid μ-receptors in mice, and such scratching was due to a sensation, probably itching. The present animal model may be useful for analyzing opioid-mediated central itching.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 74 (1), 77-82, 1997

  公益社団法人 日本薬理学会

キーワード

• Opioid
• Scratching
• Itch
• Intracisternal injection
• μ-Opioid receptor

詳細情報

• CRID: 1390282679261197440
• NII論文ID: 10008678482
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.74.77
• COI: 1:CAS:528:DyaK2sXjs1Gitbo%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• NDL書誌ID: 4219985
• PubMed: 9195300
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4219985
• Web Site: https://search.jamas.or.jp/link/ui/1997209658
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可