Acetylcholine-induced relaxation of rat aorta is greatest during estrus in sexual cycle

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  • Honda Hideo
    Department of Pharmacology, Tokyo University of Pharmacy and Life Science
  • Ishihara Hisayuki
    Department of Pharmacology, Tokyo University of Pharmacy and Life Science
  • Takei Mai
    Department of Pharmacology, Tokyo University of Pharmacy and Life Science
  • Kogo Hiroshi
    Department of Pharmacology, Tokyo University of Pharmacy and Life Science

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タイトル別名
  • Acetylcholine-Induced Relaxation of Rat Aorta Is Greatest during Estrus in the Sexual Cycle.
  • Acetylcholine-Induced Relaxation of Rat

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抄録

Acetylcholine (ACh)-induced relaxation in the aortae precontracted with norepinephrine was significantly enhanced in the aortae from estrus (E)rats, compared with that in those from metestrus (D-1), diestrus (D-2)and proestrus (PE)rats. NG-Nitro-L-arginine methyl ester (L-NAME)inhibited the endothelium-dependent relaxation in E rats. These results suggest that there is a difference in ACh-induced relaxation of the thoracic aorta during the sexual cycle of rats, and the relaxation is greatest in E of the sexual cycle; this may be due to a difference in nitric oxide synthesis in the endothelium in the sexual cycle.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 74 (1), 113-115, 1997

    公益社団法人 日本薬理学会

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