Acetylcholine-Induced Relaxation of Rat Aorta Is Greatest during Estrus in the Sexual Cycle

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Acetylcholine (ACh)-induced relaxation in the aortae precontracted with norepinephrine was significantly enhanced in the aortae from estrus (E)rats, compared with that in those from metestrus (D-1), diestrus (D-2)and proestrus (PE)rats. <I>N</I><SUP>G</SUP>-Nitro-L-arginine methyl ester (L-NAME)inhibited the endothelium-dependent relaxation in E rats. These results suggest that there is a difference in ACh-induced relaxation of the thoracic aorta during the sexual cycle of rats, and the relaxation is greatest in E of the sexual cycle; this may be due to a difference in nitric oxide synthesis in the endothelium in the sexual cycle.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 74(1), 113-115, 1997-05-01

    The Japanese Pharmacological Society

参考文献:  11件中 1-11件 を表示

被引用文献:  1件中 1-1件 を表示

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各種コード

  • NII論文ID(NAID)
    10008678611
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4219992
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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