Beneficial Effects of Dilazep on the Palmitoyl : L : carnitine : Induced Derangements in Isolated, Per fused Rat Heart: Comparison with Tetrodotoxin

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The present study was carried out to determine the effect of dilazep, having an inhibitory effect on the Na<SUP>+</SUP> channel, on the mechanical dysfunction and metabolic derangements induced by palmitoyl-L-carnitine in isolated rat heart and to compare the effect of dilazep with that of tetrodotoxin, a specific inhibitor of the Na<SUP>+</SUP> channel. Rat hearts were perfused aerobically at a constant flow according to Langendorff s technique and paced electrically. Palmitoyl-L-carnitine (5 μM)decreased the left ventricular developed pressure and increased the left ventricular end diastolic pressure (i.e., it produced mechanical dysfunction), decreased the tissue level of adenosine triphosphate and increased the tissue level of adenosine monophosphate (i.e., it produced metabolic derangements). These mechanical and metabolic alterations induced by palmitoyl-L-carnitine were attenuated by either dilazep (1 μM)or tetrodotoxin (3 μM). On the other hand, neither dilazep nor tetrodotoxin modified the mechanical function and energy metabolism of the normal (palmitoyl-L-carnitine-untreated)heart. These results suggest that inhibition of the Na<SUP>+</SUP> channel with dilazep or tetrodotoxin is responsible, at least in part, for attenuating the palmitoyl-L-carnitineinduced mechanical dysfunction and metabolic derangements in the heart.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 74(2), 147-153, 1997-06-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008678811
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4260343
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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