Neuroprotective Effect of YM90K, an AMPA-Receptor Antagonist, against Dclayed Neuronal Death Induced by Transient Global Cerebral Ischemia in Gerbils and Rats

この論文にアクセスする

この論文をさがす

著者

抄録

We investigated the neuroprotective effect of the α-amino-3-hydroxy-5-methylisoxazole-4propionate (AMPA)-receptor antagonist YM90K in transient global ischemia models. In a gerbil model, transient ischemia was induced by bilateral common carotid artery (CCA)occlusion for 5 min. On administration at 1 hr after ischemia, the AMPA antagonists NBQX (30 mg/kg, i.p. × 3)and YM90K (15 mg/kg, i.p. × 3 or 30 mg/kg, i.p. × 3)significantly reduced the delayed neuronal death in the hippocampal CA1 region from 4 days after bilateral CCA occlusion. Furthermore, YM90K (30 mg/kg, i.p. × 3)showed a neuroprotective effect even when given at 6 hr after ischemia. In contrast, the <I>N</I>-methyl-D-aspartate receptor antagonists CGS19755, MNQX (30 mg/kg, i.p. × 3, each)and (±)MK-801 (10 mg/kg, i.p.)were not effective on injection at 1 hr after ischemia in this model. In a rat model, ischemia was induced by 4-vessel occlusion (4-VO)for 10 min. YM90K was administered 60 min after reperfusion. Rectal and temporal muscle temperatures were maintained at the same level as in the control group for 6 hr. YM90K markedly prevented the development of delayed neuronal death from 7 days after 4-VO at doses of 15 or 30 mg/kg, i.p. × 3, with neuroprotective efficacy similar to that in the gerbil model. These results suggest that the AMPA receptor plays a critical role in the development of the delayed neuronal death induced by transient global cerebral ischemia. They also suggest that the neuroprotective effect of YM90K is not related to its hypothermic effect.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 74(3), 253-260, 1997-07-01

    The Japanese Pharmacological Society

参考文献:  33件中 1-33件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008679247
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4260357
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ