Cimetidine Inhibits the Induction of Long-Term Potentiation in the Dentate Gyrus of Rats In Vivo

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We investigated the effect of cimetidine, a clinically used H<SUB>2</SUB>-receptor antagonist, on the induction of long-term potentiation (LTP)in the dentate gyrus of anesthetized rats. Intracerebroventricular injection of cimetidine (50-100 nmol)inhibited the induction of LTP in a dose-dependent manner. The inhibitory effect of cimetidine was not mimicked by other H<SUB>2</SUB>-receptor antagonists (ranitidine, famotidine)or the H<SUB>1</SUB>-receptor antagonist diphenhydramine or the H<SUB>3</SUB>-receptor antagonist thioperamide. These results suggest that cimetidine inhibits hippocampal synaptic plasticity by a novel brain mechanism unrelated to H<SUB>1</SUB>, H<SUB>2</SUB> or H<SUB>3</SUB> receptors.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 74(3), 281-283, 1997-07-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008679372
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4260361
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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