Role of Cellular Na^+ Accumulation in Acetylcholine-Induced Desensitization of Guinea Pig Ileal Longitudinal Muscle

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The role of cellular Na<SUP>+</SUP> accumulation in acetylcholine-induced desensitization was investigated in guinea pig ileal longitudinal muscle. Desensitization was induced by the pretreatment with acetylcholine (10<SUP>-4</SUP> M, 30 min)and was expressed by the rightward shift in the concentration-response curve for acetylcholine after the treatment. The same treatment with acetylcholine caused accumulation of cellular Na<SUP>+</SUP> that amounted to about 3.5-fold of the control level. To study the relationship between the gain of cellular Na<SUP>+</SUP> and the development of desensitization, we treated the muscle strips with acetylcholine under the condition in which the external Na<SUP>+</SUP> concentration ranged from zero to 149.2 mM. The result showed that cellular Na<SUP>+</SUP> content is closely related to the extent of desensitization; that is, desensitization was at the lowest level when acetylcholine induced no increase in cellular Na<SUP>+</SUP>, while desensitization developed in proportion to the increase in cellular Na<SUP>+</SUP> content. However, when cellular Na<SUP>+</SUP> was increased by another method (by the treatment with ouabain), the inhibition of the acetylcholine response was far less than that observed in the case of desensitization. We concluded that both muscarinic stimulation and the accompanying accumulation of cellular Na<SUP>+</SUP> are required for desensitization to occur in full. This desensitization could be the result of a muscarinic stimulated and cellular Na<SUP>+</SUP>-dependent mechanism.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 74(4), 291-295, 1997-08-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008679404
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4287824
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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