Immunopharmacological Studies on Collagen-Induced Arthritis in Dark Agouti (DA) Rats

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Dark Agouti (DA)and Lewis rat strains were tested for susceptibility to collagen-induced arthritis (CIA)and for development of cellular and humoral immune responses to type II collagen (CII). All of the DA rats developed arthritis following a single intradermal injection of more than 20 μg of CII (130-150 μg/kg rat weight)and showed a swelling rate of more than 100% in the hind paws. The swelling rate showed little deviation among the animals. There was a strong correlation between the severity of the arthritis and the strength of the immune response to CII in DA rats with CIA. Following immunization with even 800 μg of CII (3.8-4.2 mg/kg rat weight), Lewis rats showed a maximum rate of hind paw swelling of only 45%. In the pharmacological studies, prednisolone, indomethacin, FK-506 and mizoribine all suppressed arthritis in DA rats. These findings suggest that DA rats are more susceptible to CIA than Lewis rats and that CIA in DA rats as well as in Lewis rats is serviceable as an experimental animal model of rheumatoid arthritis.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 74(4), 313-322, 1997-08-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008679482
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4287827
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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