Centrally Applied Nitric Oxide Donors Inhibit Vagally Evoked Rat Gastric Acid Secretion: Involvement of Sympathetic Outflow

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Intracerebroventricularly (i.c.v.)administered nitric oxide (NO)donors, 3-morpholinosydnonimine (SIN-1)(100-500 μg/animal)and sodium nitroprusside (SNP)(100-250 μg/animal)dosedependently inhibited the rat gastric acid secretion evoked by vagal stimulation at 3 Hz. Furthermore, the inhibitory effect of SIN-1 (250 μg/animal)was more marked and its onset was more rapid than that of SNP (250 μg/animal). The SIN-1 (250 μg/animal)-induced antisecretory effect was abolished by both splanchnicotomy and phentolamine (5 mg/kg, i.m.), and also by indomethacin (500 μg/animal, i.c.v.). These results suggest that i.c.v. administered NO donors inhibit vagally evoked gastric acid secretion by activation of central sympathetic outflow. Central prostaglandin is probably implicated in this NOmediated antisecretory effect.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 74(4), 337-340, 1997-08-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008679557
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4287830
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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