Effects of Various Selective Phosphodiesterase Inhibitors on Muscle Contractility in Guinea Pig Ileal Longitudinal Smooth Muscle

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The effects of various selective phosphodiesterase (PDE) inhibitors on muscle contractility in guinea pig ileal longitudinal smooth muscle were investigated. 1) 3-Isobutyl-l-methyl xanthine (IBMX) or zaprinast markedly inhibited the high K<SUP>+</SUP> or carbachol (CCh)-induced contraction and increased cGMP content of the muscle strip in a concentration-dependent manner. However, these agents only slightly increased the cAMP content. Milrinone or Ro20-1724 also slightly inhibited the high K<SUP>+</SUP> or CCh-induced contraction and increased the cAMP content, but did not increase cGMP. 2) In a fura2-loaded muscle, IBMX or zaprinast inhibited both contractions and the increase in intracellular Ca<SUP>2+</SUP> ([Ca<SUP>2+</SUP>]<SUB>i</SUB>) level induced by high K<SUP>+</SUP> or CCh, although the inhibitory effect on the [Ca<SUP>2+</SUP>]i level was smaller than that on muscle tension. 3) In α-toxin-permeabilized muscles, cGMP, IBMX or zaprinast significantly inhibited the Ca<SUP>2+</SUP>induced contraction. These results suggest that IBMX and zaprinast inhibit muscle contraction in the ileal longitudinal smooth muscles mainly through an increase in cGMP and the inhibitory mechanism of IBMX or zaprinast is involved in the decreases in the [Ca<SUP>2+</SUP>]<SUB>i</SUB> level and sensitivity of contractile elements to Ca<SUP>2+</SUP>.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 75(1), 77-85, 1997-09-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008679804
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4307647
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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