Effect of Lecithinized-Superoxide Dismutase on the Interstitial Pneumonia Model Induced by Bleomycin in Mice.

• Yamazaki Chihiro

  Tokyo Research Institute, Seikagaku Corporation

• Hoshino Jiro

  Tokyo Research Institute, Seikagaku Corporation

• Hori Yusuke

  Tokyo Research Institute, Seikagaku Corporation

• Sekiguchi Tomoko

  Tokyo Research Institute, Seikagaku Corporation

• Miyauchi Satoshi

  Tokyo Research Institute, Seikagaku Corporation

• Mizuno Syoji

  Tokyo Research Institute, Seikagaku Corporation

• Horie Katsuyuki

  Tokyo Research Institute, Seikagaku Corporation

書誌事項

タイトル別名

• Effect of Lecithinized-Superoxide Dismu

抄録

Superoxide anion (0₂^-) acts as an exacerbation factor in interstitial pneumonia. Lecithinized-superoxide dismutase (PC-SOD), which is synthesized with a lecithin derivative bound covalently to recombinant human Cu, Zn-SOD, has a longer half-life in plasma and higher affinity to cell membranes than unmodified SOD. The effect of PC-SOD was evaluated using the bleomycin-induced interstitial pneumonia mouse model. Treatment with PC-SOD at 10 mg/kg significantly reduced the hydroxyproline content and fibrosis score. Namely, PC-SOD suppressed the progression of pulmonary fibrosis on the bleomycin-induced interstitial pneumonia mouse model. PC-SOD may be a potential drug for interstitial pneumonia therapy.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 75 (1), 97-100, 1997

  公益社団法人 日本薬理学会

キーワード

• Lecithinized-superoxide dismutase
• nterstitial pneumonia
• Bleomycin

詳細情報

• CRID: 1390282679264198400
• NII論文ID: 10008679859
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.75.97
• COI: 1:CAS:528:DyaK2sXmtl2qtLc%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4307650
• PubMed: 9334891
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4307650
• Web Site: https://search.jamas.or.jp/link/ui/1998126383
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可