Effect of Salmon-Calcitonin In Vitro Opioid Withdrawal

DOI Web Site PubMed 参考文献15件
  • Alfaro M. Jose
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid
  • Fernandez Beatriz
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid
  • Goicoechea Carlos
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid
  • Martin M. Isabel
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid

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タイトル別名
  • Effect of Salmon-Calcitonin on In Vitro Opioid Withdrawal.
  • Effect of Salmon-Calcitonin In Vitro Op

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抄録

The effect on the in vitro withdrawal sign induced by naloxone in morphine-dependent guinea pig ileum has been analyzed. Salmon calcitonin (s-CT) dose-dependently reduced the force of the contraction induced by naloxone in morphine incubated tissues, but did not modify the contraction induced by administration of acetylcholine or substance P in non-treated tissues. Therefore, the effect of s-CT in morphine incubated tissues may not be attributable to postsynaptic mechanisms, and an inhibitory modulation of the excitatory pathways triggered by naloxone would be suggested. In conclusion, s-CT is able to prevent the withdrawal sign in vitro.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 75 (1), 101-104, 1997

    公益社団法人 日本薬理学会

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