Coronary Artery Diameter Increase Induced by a Phosphodiesterase 5 Inhibitor, E4021, in Conscious Pigs

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抄録

The effects of intravenous infusions of 1, 3 and 10 μg/kg/min of the phosphodiesterase 5 inhibitor, E4021, at 30-min intervals on coronary artery diameter were studied in 8 conscious pigs monitored with a pair of piezoelectric crystals. The highest dose increased the diameter by 2.9±0.5% (P<0.01 vs vehicle) of the baseline diameter, with a significant decrease in mean pulmonary arterial pressure. However, there were no changes in mean aortic pressure and heart rate. Additionally, E4021 significantly prolonged the duration of the diameter increase induced by nitroglycerin. Thus, phosphodiesterase 5 inhibition causes coronary artery diameter increase and produces an amplifying effect with nitroglycerin.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 77(1), 99-102, 1998-05-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008680307
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4503679
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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