Dexamethasone Prevents the Decrease of Bone Mineral Density in Type II Collagen-Induced Rat Arthritis Model.

• Takagi Toshiki

  Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory

• Tsao Peter W.

  Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory

• Totsuka Ryuichi

  Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory

• Suzuki Tatsuo

  Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory

• Murata Takashi

  Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory

• Takata Isao

  Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory

Bibliographic Information

Other Title

• Dexamethasone Prevents the Decrease of Bone Mineral Density in Type 2 Collagen-Induced Rat Arthritis Model
• Dexamethasone Prevents the Decrease of

Abstract

This study demonstrated the decrease of bone mineral density (BMD) in the type II collagen (CII)-induced arthritis (CIA) model in rats and the relationship between BMD and paw edema and the effect of dexamethasone-21-phosphate (DEX). The paw swelling occurred on Day 10 and reached its peak on Day 18 after CII injection. BMD in the CII-injected group is lower than that in the control group. BMD in the proximal and distal regions of the femur largely decreased in comparison with that of the middle region. The oral administration of DEX (0.1 mg/kg) inhibited the swelling and decrease of BMD in all three regions of the femur.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 78 (2), 225-228, 1998

  The Japanese Pharmacological Society

Keywords

• Collagen-induced arthritis
• Bone mineral density
• Dexamethasone

Details

• CRID: 1390001204287071360
• NII Article ID: 10008680885
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.78.225
• COI: 1:CAS:528:DyaK1cXmvFyqsLw%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 4591520
• PubMed: 9829626
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4591520
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819310510?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819310510?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/78/2/78_2_225/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999070714
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed