Memory Facilitation and Stimulation of Endogenous Nerve Growth Factor Synthesis by the Acetylcholine Releaser PG-9.
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- Ghelardini Carla
- Department of Pharmacology, University of Florence
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- Galeotti Nicoletta
- Department of Pharmacology, University of Florence
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- Bartolini Alessandro
- Department of Pharmacology, University of Florence
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- Furukawa Shoei
- Department of Molecular Biology, Gifu Pharmaceutical University
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- Nitta Atsumi
- Department of Molecular Biology, Gifu Pharmaceutical University
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- Manetti Dina
- Department of Pharmaceutical Sciences, University of Florence
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- Gualtieri Fulvio
- Department of Pharmaceutical Sciences, University of Florence
書誌事項
- タイトル別名
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- Memory Facilitation and Stimulation of
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The effects of PG-9 (3α-tropyl 2-(p-bromophenyl)propionate), the acetylcholine releaser, on memory processes and nerve growth factor (NGF) synthesis were evaluated. In the mouse passive-avoidance test, PG-9 (10 - 30 mg/kg, i.p.), administered 20 min before the training session, prevented amnesia induced by both the non selective antimuscarinic drug scopolamine and the M1-selective antagonist S-(-)-ET-126. In the same experimental conditions, PG-9 (5 - 20 μg per mouse, i.c.v.) was also able to prevent antimuscarine-induced amnesia, demonstrating a central localization of the activity. At the highest effective doses, PG-9 did not produce any collateral symptoms as revealed by the Irwin test, and it did not modify spontaneous motility and inspection activity, as revealed by the hole-board test. PG-9 was also able to increase the amount of NGF secreted in vitro by astrocytes in a dose-dependent manner. The maximal NGF contents obtained by PG-9 were 17.6-fold of the control value. During culture, no morphological changes were found at effective concentrations of PG-9. The current work indicates the ability of PG-9 to induce beneficial effects on cognitive processes and stimulate activity of NGF synthesis in astroglial cells. Therefore, PG-9 could represent a potential useful drug able to improve the function of impaired cognitive processes.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 78 (3), 245-251, 1998
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204286056832
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- NII論文ID
- 10008680957
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXnslykt7k%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4610812
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- PubMed
- 9869257
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4610812
- https://api.elsevier.com/content/article/PII:S0021519819310224?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819310224?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/3/78_3_245/_pdf
- https://search.jamas.or.jp/link/ui/1999099333
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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