Tamsulosin: α_1 : Adrenoceptor Subtype : Selectivity and Comparison With Terazosin

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抄録

Selectivity of tamsulosin and terazosin to functional α<SUB>1</SUB>-adrenoceptors was examined. Both drugs competitively inhibited the contractile responses to noradrenaline in different tissues where the responses were mediated through the α<SUB>1D</SUB>-, α<SUB>1B</SUB>- or α<SUB>1L</SUB>-subtype. Together with the affinities obtained in the binding study with cloned (α<SUB>1a</SUB>, α<SUB>1b</SUB>, α<SUB>1d</SUB>) and native (α<SUB>1A</SUB> and α<SUB>1B</SUB>) subtypes, the selectivity of tamsulosin was α<SUB>1A</SUB>>α<SUB>1L</SUB>, α<SUB>1D</SUB>>α<SUB>1B</SUB>. Terazosin had lower affinity at various subtypes than tamsulosin, but showed relatively high selectivity to the α<SUB>1D</SUB>-subtype. In the human prostate, tamsulosin was more than 30-fold higher in affinity than terazosin in functional and binding studies.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 78(3), 331-335, 1998-11-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008681276
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4610822
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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