A Comparative Study on the Effects of Nicotine and GTS-21, a New Nicotinic Agonist, on the Locomotor Activity and Brain Monoamine Level.

• Nanri Masato

  Department of Pharmacology, Taiho Pharmaceutical Co., Ltd. Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

• Kasahara Nobuo

  Department of Pharmacology, Taiho Pharmaceutical Co., Ltd.

• Yamamoto Jyunji

  Department of Pharmacology, Taiho Pharmaceutical Co., Ltd.

• Miyake Hidekazu

  Department of Pharmacology, Taiho Pharmaceutical Co., Ltd.

• Watanabe Hiroshi

  Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

Bibliographic Information

Other Title

• A Comparative Study on the Effects of N

Abstract

Effects of GTS-21 [3-(2, 4-dimethoxybenzylidene)-anabaseine dihydrochloride], a selective nicotinic agonist, on locomotor activity and dopamine turnover were examined and compared to those of nicotine to test if GTS-21 exhibits side effects similar to those of nicotine. GTS-21 had no effect on locomotor activity in mice or dopamine turnover in rats. In contrast, nicotine produced a biphasic effect on locomotor activity. It also enhanced dopamine turnover rates in the striatum and cerebral cortex, suggesting the involvement of dopaminergic systems in the nicotine-induced changes in locomotor activity. GTS-21 exhibits fewer adverse effects, suggesting that it has therapeutic potential for cognitive disorders related to central cholinergic dysfunction.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 78 (3), 385-389, 1998

  The Japanese Pharmacological Society

Keywords

• GTS-21
• Nicotine
• Nicotinic agonist

Details

• CRID: 1390001204286088192
• NII Article ID: 10008681469
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.78.385
• COI: 1:CAS:528:DyaK1cXnslyktbo%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 4610829
• PubMed: 9869274
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4610829
• Web Site: https://api.elsevier.com/content/article/PII:S002151981931039X?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S002151981931039X?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/78/3/78_3_385/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999089073
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed