In Vitro Effects of Calcium Dobesilate on the Responsiveness of Spontaneously Diabetic Rat Aorta

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We tested the effect of calcium dobesilate (DOBE) in aorta from spontaneously diabetic (BB/wor) rats. The contraction induced by 10<SUP>-6</SUP> M noradrenaline (NA) in BB/wor rats was smaller than that induced in control rats (1.21±0.11 vs 0.82±0.02 g, P<0.01, n=8, respectively) in arteries with intact endothelium. Incubation with DOBE (10<SUP>-4</SUP> M) impaired the contractions induced by NA in BB/wor rats (1.21±0.11 vs 0.67±0.01 g, P<0.01, n=8). The effect of DOBE was reversed by 10<SUP>-6</SUP> M propranolol (0.67±0.01 vs 1.20±0.60 g, P<0.001, n=8, with 10<SUP>-4</SUP> M DOBE and 10<SUP>-4</SUP> M DOBE plus 10<SUP>-6</SUP> M propranolol, respectively). DOBE increased the endothelium-dependent relaxation in arteries from diabetic rats. These findings suggest that DOBE might improve vascular reactivity in BB/wor rats.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 78(3), 391-394, 1998-11-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008681483
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4610830
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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