ATP Receptors for the Protection of Hippocampal Functions.

• Inoue Kazuhide

  Division of Pharmacology, National Institute of Health Sciences

Bibliographic Information

Other Title

• ATP Receptors for the Protection of Hip

Abstract

The inhibitory effects of extracellular adenosine 5′-triphosphate (ATP) are reviewed in the present paper. ATP inhibits the release of the excitatory transmitter glutamate and stimulates the release of the inhibitory transmitter GABA from hippocampal neurons. Also, ATP activates potassium conductance directly through G protein, resulting in hyperpolarization of membrane potential. ATP activates microglia to secrete plasminogen that promotes the development of mesencephalic dopaminergic neurons and enhances neurite outgrowth from explants of neocortical tissue. Moreover, ATP may protect hippocampal neurons from excitotoxic cell death by preserving mitochondrial function. Thus, ATP may have a role in the protection of the function of hippocampus from over-stimulation by glutamate.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 78 (4), 405-410, 1998

  The Japanese Pharmacological Society

Keywords

• ATP
• Hippocampus
• Neuron
• Protection
• Excitotoxicity

Details

• CRID: 1390001204287110400
• NII Article ID: 10008681546
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.78.405
• COI: 1:CAS:528:DyaK1MXhvFWmsA%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 4629544
• PubMed: 9920196
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4629544
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819310030?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819310030?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/78/4/78_4_405/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999112183
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed