Anti-ulcer Effects of Antioxidants, Quercetin, a-Tocopherol, Nifedipine and Tetracycline in Rats

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When free radical-scavenging activities of quercetin, α-tocopherol, nifedipine and tetracycline were measured by an electron spin resonance technique, all test compounds (10<SUP>-5</SUP> to 10<SUP>-3</SUP> M) scavenged both superoxide anions and hydroxyl radicals. The oral administration of quercetin (50 and 100 mg/kg), α-tocopherol (8 and 16 mg/kg), nifedipine (20 and 40 mg/kg) or tetracycline (10 and 20 mg/kg) markedly prevented the HCl plus ethanol-induced gastric mucosal injury and the increase in the content of thiobarbituric acid-reactive substances in the injured mucosa in rats. In addition, quercetin (25, 50 and 100 mg/kg), α-tocopherol (4, 8 and16 mg/kg), nifedipine (10, 20 and 40 mg/kg) and tetracycline (5, 10 and 20 mg/kg), given orally, twice daily for 14 consecutive days from the day after acetic acid injection, dose-dependently promoted the ulcer healing and inhibited the increase in the content of thiobarbituric acid-reactive substances in the ulcerated mucosa. These results indicate that quercetin, α-tocopherol, nifedipine and tetracycline possess gastric cytoprotective and gastric ulcer healing-promoting actions. In addition, the free radical-scavenging properties of these compounds may be partly related to their anti-ulcer effects.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 78(4), 435-441, 1998-12-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008681680
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4629548
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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