Heroin Antinociception Changed From Mu to Delta Receptor in Streptozotocin-Treated Mice

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CD-1 mice were treated intravenously with streptozotocin, 200 mg/kg, and tested 2 weeks later or treated with 60 mg/kg and tested 3 days later. Both treatments changed the tail flick response of heroin and 6-monoacetylmorphine (6 MAM) given intracerebroventricularly from a μ- to δ-opioid receptor-mediated action as determined by differential effects of opioid receptor antagonists. The response to morphine remained μ. Heroin and 6 MAM responses involved δ<SUB>1</SUB> (inhibited by 7-benzylidenenaltrexone) and δ<SUB>2</SUB> (inhibited by naltriben) receptors, respectively. These δ-agonist actions did not synergize with the μ-agonist action of morphine in the diabetic mice. The expected synergism between the δ agonist, [D-Pen<SUP>2</SUP>-D-Pen<SUP>5</SUP>]enkephalin (DPDPE), and morphine was not obtained in diabetic mice. Thus, diabetes disrupted the purported μ/δ-coupled response. In nondiabetic CD-1 mice, heroin and 6 MAM produced a different μ-receptor response (not inhibited by naloxonazine) from that of morphine (inhibited by naloxonazine). Also, these μ actions, unlike that of morphine, did not synergize with DPDPE. The unique receptor actions and changes produced by streptozotocin suggest that extrinsic in addition to genetic factors influence the opioid receptor selectivity of heroin and 6 MAM.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 78(4), 443-454, 1998-12-01

    公益社団法人 日本薬理学会

参考文献:  39件中 1-39件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008681706
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4629549
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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