Serotonin Receptor Subtypes Involved in Modulation of Electrical Acupuncture

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抄録

We examined the effects of intravenous injection of several serotonin (5-HT) antagonists on the inhibitory action of electro-acupuncture (EAP) against the nociceptive responses in the trigeminal nucleus caudalis in rabbits. The inhibitory effect of EAP was suppressed by pindolol, methysergide and ICS 205-930, whereas NAN-190 and ketanserin amplified the EAP effect. These results suggest that 5-HT<SUB>1</SUB>, except 5-HT<SUB>1A</SUB>; 5-HT<SUB>2</SUB>, except 5-HT<SUB>2A</SUB>; and 5-HT<SUB>3</SUB> receptors are positively involved in EAP-induced analgesia, whereas the activation of 5-HT<SUB>1A</SUB> and 5-HT<SUB>2A</SUB> receptors suppressively act on EAP-induced analgesia.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 78(4), 511-514, 1998-12-01

    The Japanese Pharmacological Society

参考文献:  15件中 1-15件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008681986
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4629558
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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